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Lificiguat
Formula: C17H14N8S
Discovery of XL888: a novel tropane-derived small molecule inhibitor of HSP90
reaching a maximum increase of 1
InChiKey: MBPXGBINIINSEU-UHFFFAOYSA-N
LY2228820 Catalog No.:M10824-10 LificiguatRalimetinib, also known as LY2228820, is a potent and selective, ATP competitive inhibitor of the and isoforms of p38 MAPK in vitro (IC(50) = 5. 3 and 3. 2 nmol L, respectively). In cell based assays, LY2228820 potently and selectively inhibited phosphorylation of MK2 (Thr334) in anisomycin stimulated HeLa cells (at 9. 8 nmol L by Western blot analysis) and anisomycin induced mouse RAW264. 7 macrophages (IC(50) = 35. 3 nmol L) with no changes in
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